|
KMID : 1003219990050010245
|
|
Journal of Korean Oriental Chronic Disease
1999 Volume.5 No. 1 p.245 ~ p.261
|
|
|
The Effects of Sagunjatanghapchangchuljiyutang against Gastric Mucosal Lesions
|
|
|
|
|
Abstract
|
|
|
Purpose : This study is to investigate the protective effects of Sagunjatangac - angchuljiyutang against gastric mucosal lesions.
Methods : The test group was injected with indomethacin after the oral administration of Sagunjatanghapchangchuljiyutang, while the control group was injected only with normal-saline and INDO group was injected only with indomethacin. The effects of Sagunjatanghapchangchuljiyutang extract administration on lipid peroxidation, morphology of gastric mucosa, mucous-secreting cell, distribution of PNA and ICAM in mice suffered from indomethacin -induced gastric mucosal lesions.
Results are as follows :
1. The degree of lipid peroxidation in Sagunjatanghapchangchuljiyutang group conspicuously decreased as compared with INDO group.
2. The normal morphology of gastric mucosa was maintained in mice subcutaneously injected with Sagunjatanghapchangchuljiyutang.
3. The normal configuration of mucous-secreting cell was maintained in mice intra gastric injected with Sagunjatanghapchangchuljiyutang.
4. The distribution of PNA in Sagunjatanghapchangchuljiyutang group was as same as control group(normal gastric mucosa).
5. The distribution of ICAM in Sagunjatanghapchangchuljiyutang group was appeared a little as same as control group.
Conclusion : Sagunjatanghapchangchuljiyutang has protective effects against gastric mucosal lesions and some remedial action would be also considered.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|